Such favorable properties will continue to keep UFH and its derivatives, the low-molecular-weight heparins LMWHs , at the therapeutic forefront for a number of indications where alternative therapies are currently lacking cardiac surgery , unsuitable mechanical valves , or untested cancer associated thrombosis and antiphospholipid antibody syndrome. It is an immune complication caused by antibodies directed to complexes containing heparin and an endogenous platelet protein, platelet factor 4 PF4. A time line of some of the landmark studies, in the opinion of the author, is provided in Figure 1. For a detailed historical perspective on HIT, the reader is referred to the excellent review by Kelton and Warkentin. A time line of key clinical and laboratory-based observations in HIT. Important clinical developments are provided above the time band, and major research observations are noted below.
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Nejm Heparin Induced Thrombocytopenia
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Heparin Induced Thrombocytopenia Nejm